Modeling intra-tumor protein expression heterogeneity in tissue microarray experiments
نویسندگان
چکیده
منابع مشابه
Modeling intra-tumor protein expression heterogeneity in tissue microarray experiments.
Tissue microarrays (TMAs) measure tumor-specific protein expression via high-density immunohistochemical staining assays. They provide a proteomic platform for validating cancer biomarkers emerging from large-scale DNA microarray studies. Repeated observations within each tumor result in substantial biological and experimental variability. This variability is usually ignored when associating th...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2008
ISSN: 0277-6715
DOI: 10.1002/sim.3217